Tottenham v Borussia Dortmund
Tottenham kicked off their Premier League campaign with a 2-0 defeat of Newcastle before succumbing to a 2-1 loss to Chelsea. A 1-1 draw with Burnley was to follow before getting back on track by confidently defeating Everton.
Dortmund, meanwhile, eased past Wolfsburg 3-0 and beat Hertha BSC 2-0 before being stunned to a 0-0 stalemate with Freiburg this past weekend.
Ahead of the clash, Spurs boss Mauricio Pochettino said: "I think it is a very competitive team. They play so well. They have very good players.
"They are so dynamic and they always try to respect and play the ball along the grass and I think it will be very, very tough for both sides to compete tomorrow.
"I think always to start well in that competition, in the Champions League. It will be key for the future."
Dortmund manager Peter Bosz added: "The first game is always important. We're approaching the game like any other and we're here to win.
"Spurs have a similar philosophy to us. I'm expecting a good game. I want us to be brave."
In team news, Spurs are without Dele Alli as he starts a three-game European ban.
Erik Lamela (hip), Danny Rose (knee) and Victor Wanyama (knee) are all still injured.
Dortmund have a number of players missing, including Neven Subotic (ill), Marcel Schmelzer (ankle ligaments), Marc Bartra (groin), Julian Weigl (ankle), Andre Schurrle (thigh), Sebastian Rode (knock), Erik Durm (hip), Raphael Guerreiro (foot) and Marco Reus (knee).